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Pulmonary alveolar microlithiasis: an interesting case report with systematic review of Indian literature

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《医学前沿（英文）》 2015年第9卷第2期页码 229-238 doi: 10.1007/s11684-015-0394-y

摘要：

Pulmonary alveolar microlithiasis is a rare disease characterized by intra-alveolar presence of microliths. This study reports an interesting case of pulmonary alveolar microlithiasis and provides a systematic review of cases reported from India. A 23-year-old female presented with a history of cough, wheeze, chest pain, and episodic wheeze for five months. Pulmonary function tests demonstrated an obstructive pattern, and chest X-ray showed fine micronodular opacities predominantly involving the middle and lower zones of both lungs. Transbronchial lung biopsy revealed the diagnosis. She responded well to inhaled steroid therapy. A systematic review of literature was performed and identified 73 cases of pulmonary alveolar microlithiasis reported from India. The mean (SD) age of the patients was 28.8 (14.9) years, with an almost equal male:female ratio. Many patients were asymptomatic at presentation. Breathlessness and cough were the most common symptoms, and the disease progressed into respiratory failure associated with cor pulmonale. About one-third of the cases were initially misdiagnosed and treated as pulmonary tuberculosis. Extra-pulmonary manifestations and co-morbidities were also evident in our series. This systematic review helps to determine epidemiological and clinical characteristics of pulmonary alveolar microlithiasis. Further research is needed to elucidate the etiopathogenesis, diagnosis, and therapeutic options, which are beneficial in developing and identifying cost-effective treatment for pulmonary alveolar microlithiasis.

关键词： pulmonary alveolar microlithiasis alveolar microlithiasis microliths rare diseases

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Long-term remodeling of anterior alveolar bone from treatment to retention

Yan LIU MD, Jiuhui JIANG MD, Tianmin XU MD, Haiping ZHANG MD,

《医学前沿（英文）》 2009年第3卷第4期页码 408-414 doi: 10.1007/s11684-009-0069-7

摘要： Bone remodeling in orthodontic treatment has been one of the most concerned issues. The purpose of this study was to characterize the changes in bone remodeling on both labial and lingual aspects of the anterior teeth during treatment and retention. Data of 55 extraction cases (41 females and 14 males) were collected at pretreatment, post-treatment, and follow-up stages. Bone thickness on both labial and lingual aspects of the upper and lower incisors were measured at the level of the center of resistance (UC and LC) and that of 3mm apical to the upper and lower incisors’ center of resistance (UAC and LAC). For LC, with the significant lingual movement of point LIR (center of resistance of lower incisor; <0.001), no statistically significant changes in alveolar width on the labial aspect were detected, whereas the reduction of lingual alveolar width was statistically significant (<0.001). In retention, no significant movement of point LIR appeared to occur, while an increase in alveolar width on the lingual aspect was found at this stage. For LAC, the changes in alveolar width as well as the displacement of point LIA (apex of lower incisor) were similar to those of LC. On the maxilla, with the control lingual tipping movement of upper incisor, most of the anterior alveolar changes surrounding the upper incisor were analogous to those of lower incisor. But differently, during treatment, labial bone thickness was increased significantly as the upper incisor moved lingually, and in retention, no statistically significant changes were found on both labial and lingual bone thickness as the upper incisor labially proclined. It was concluded that, with lingual movement of the incisors, bone apposition on the lingual aspect may lag behind the incisor movement. In retention, the lower incisors are in a stable position, with sequential bone apposition being presented on the lingual aspect. However, the upper incisors turn out to be labially relapsed along with the lingual bone resorption and labial bone apposition occurring simultaneously.

关键词： alveolus remodeling orthodontics extraction